Transcript
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Welcome to the Dear Menopause podcast.
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I'm Sonya Lovell, your host Now.
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I've been bringing you conversations with amazing menopause experts for over two years now.
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If you have missed any of those conversations, now's the time to go back and listen, and you can always share them with anyone you think needs to hear them.
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This way, more people can find these amazing conversations, needs to hear them.
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This way, more people can find these amazing conversations.
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Dr Kelly Casperson, welcome to this week's episode of Dear Menopause.
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Thanks for having me Always a pleasure.
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Now it's actually been gosh almost three years, I think, since we actually last sat down and chatted, because you were one of my really early guests on Dear Menopause, and so much has happened in that time.
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The world's changed right Like.
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Three years is a long time in how fast menopause is changing right now.
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Absolutely.
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The narrative has changed.
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You know, the landscape has changed.
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There are so many women now that are much more aware and educated and looking for support, and I feel like your story and the support that you put out, particularly on your podcast and on Instagram and places like that, has changed a bit as well.
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What a great opportunity for a bit of a refresher.
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How about you tell everybody a little bit about who you are and where you're from?
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Yeah, thank you.
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So I'm Dr Kelly Casperson.
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I'm from the States.
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For people who are familiar with all of them, I was born in Minnesota, did urology training, so that's medical school and then surgery for urology, which is kidneys, bladder, changed probably about seven years.
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They always say the seven-year itch, right Like you get a little bored in your career, what are you doing with your life?
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And it was the perfect time for a woman to come into my office with really big sexual health issues that were super distressing and I realized I didn't know how to help her.
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So I went pretty deep into female sexual health and what's up with desire and how does orgasm work.
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And that led me into hormones.
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And I always joke that sex got me into menopause, because people are like well, you know what happens with menopause and I'm like no, like the rumor is that your sex life goes bad.
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But there's actually a lot of people whose sex life gets a lot better, which is fun to discuss.
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But you can't ignore the role of the hormones in both desire, lubrication, arousal, ability to orgasm.
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They're all desperately important.
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Can you have a good sex life without them?
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Yes, but do they help sex lives?
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Yes, so that's what I do now.
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You do and you do it so well, and you have your own podcast which is called you Are Not Broken.
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You have a book with the same name, so super easy to find Kelly and everything that she does out there in the world.
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I guess when I was talking before about how I feel like things have changed a little bit in the sense of what you talk about, I was really kind of talking about how much more we now talk about GSM.
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So the genitourinary symptoms of menopause syndrome of menopause.
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Symptoms of menopause.
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Syndrome of menopause.
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Symptoms of menopause.
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Syndrome technically, because syndrome basically means like three or more constellations of things, so it's like a collection.
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It's the medical term for collection.
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So I feel like we didn't have that terminology last time that we spoke.
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It's a little bit of something that's become, I guess, more formalized in the sense of how people talk about it.
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So I was wondering if you could just kind of bring us up to speed for anybody that's not familiar with GSM as to what that actually means.
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Yeah, so GSM means again, like you said, genital urinary symptoms or syndrome of menopause.
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Coined several years ago, more than three years ago, but before then people really talked about vaginal atrophy, for better or for worse.
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In the 1980s we called it senile vagina, but it's certainly the names.
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Yeah, so the names are getting better.
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Generally.
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Urinary syndrome and menopause is a huge mouthful, so GSM is kind of what we abbreviate it to.
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But the nice thing about it is it kind of tells you why it's happening Menopause.
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But in order for you to know, you actually have to know what menopause is right.
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So a lot of people just think menopause is like no more periods and maybe some hot flashes, and then the hot flashes end.
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That's not what, men, I mean.
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The definition of menopause is the day after a year, after no natural periods right.
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But what's actually happening is the ovarian follicles, not the eggs.
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The follicles which kind of house the eggs.
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You're basically outliving their lifespan and the follicles make hormones.
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So truly what's happening is pelvic changes because of lowering hormones.
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Typically we think about estrogen, but also testosterone does play a role in the genital structures.
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The other reason why GSM is nicer is it attributes this to the urinary things and I'm a urologist so that's important to me.
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So urinary frequency I have to pee all the time.
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Now, urgency I got to go right now.
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Like I can't wait Getting up at night to urinate, which we call nocturia Leakage leaking of bladder or urine when you don't want to Like keys in the door, running water leaking with urgency, leaking with I just my pants are almost down but I can't get there.
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Like why is this leaking before I can get there?
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Increased risk of urinary tract infections.
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They're becoming recurrent, right.
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And if you don't know that this is because of low hormones, then you don't know how to treat it and you end up just throwing antibiotics at the UTIs and overactive bladder medications at the overactive bladder, sure associated with dementia, right?
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So if you don't know why these things are happening, you can't treat it in the best, safest way that actually can resolve the problem.
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Okay, which leads us into what is the best, safest way for a woman in her midlife who's experiencing, let's say, recurrent UTIs.
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That's not antibiotics.
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Yeah, so the most.
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This is how I tell.
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This is what I say when women come to see me.
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I say if I had something that decreased the chance of you getting another UTI by 50% to 60%, would you be interested in that?
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And universally they say, yeahame this, why don't we say what can we do to decrease the chance of a next one?
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And then they're like, okay, that's not a narrative they thought they had right.
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So vaginal estrogen what it does is it repopulates lactobacillus.
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That's a microbiome.
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Microbiomes are hot topics right now, right, gut microbiome, skin microbiome, vaginal microbiome.
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So you need a healthy vaginal microbiome, skin microbiome, you know vaginal microbiome.
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So you need a healthy vaginal microbiome, which means estrogen, right?
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So as you lose your estrogen, the microbiome changes and when the microbiome changes, the vagina becomes less acidic and the acidity produced by the lactobacillus, which is your healthy microbiome, that's what prevents the poop bugs from walking up, going past the yard into the pee, right.
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And so it's like healthy vagina actually is a barrier to keep the gut microbiome where it belongs, so it doesn't start going up into the front side and that's a bladder infection.
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It's a natural prevention yeah yeah yeah, our bodies are smart, man, our bodies are super smart and and I like thinking about it that way because, well, it feels good.
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But then for women to be like we're just giving you back something that you always had right and that was protecting you, just like we'd give you back insulin or we'd give you back thyroid, we'd give you back something that you're just body, you outlived it, and so that kind of helps them understand, because if a woman doesn't understand, she's a lot less likely to go forward with the treatment.
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And the other thing that they don't understand because they don't understand that menopause is forever right.
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When those ovarian follicles stop, they don't start again is that?
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Yes, you have to use the vaginal estrogen in order for it to work.
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It's like sunscreen, right, that doesn't matter.
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If you used sunscreen last August, you still got to use it.
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I love it.
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It's a great analogy.
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Yeah, and I know I'm guilty of forgetting to use my vaginal estrogen every week or every few days.
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It's funny, right?
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I have to remind myself.
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Yeah.
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We get kind of entitled.
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Women are like I don't want to have to use it and I'm like you put a seatbelt on every time you get in the car.
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Do you floss all the time?
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You put sunscreen on all the time.
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Do you put your glasses on every time you read?
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You forget we do things all the time.
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You've got to incorporate a new thing into your system, unless you want to live with low hormones, but then that has consequences.
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It does.
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Yeah, Now, while we're on the topic of vaginal estrogen, there's a couple of things that I want to do to clarify for me I would imagine anyone that's listening or anybody new that's listening I am an estrogen positive breast cancer survivor.
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Now there is this.
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I want to say myth, but it's even more than that, because I hear stories over and over again, Like yesterday I read of a woman who was denied vaginal estrogen because she was an estrogen positive breast cancer survivor.
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Now, that's not right, is it?
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No, you're right, that's not right yeah.
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Yeah, I love that.
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Can we record that so I can replay that to my husband later?
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Yeah, I mean, we have it in America if it's useful for people who don't live in America.
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I don't know how much weight it carries, but our ACOG, which is basically the Society of Obstetrics and Gynecologists, has a position paper online that I encourage women to print out and bring to their doctors, because we, so many women think that, well, the doctor must know.
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And I have to tell you, in regards to menopause and hormones, the doctor doesn't always know.
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We have two generations, that's worldwide.
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We have two generations of trainees that didn't get trained after the Women's Health Initiative happened in 2002.
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So now we're 23 years after right.
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So don't assume that because they say you can't have it, that that's actually based in science.
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Many, many, many studies on the safety of vaginal estrogen with breast cancer survivors and I was like I mean, I'm a urologist so I always compare it to men.
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I could call prostate cancer testosterone-positive prostate cancer.
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We don't call it that right.
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So I think that it contributes to the stigma that a hormone that your body naturally makes is trying to kill you, and the better way to think about it is that hormones are like food.
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Food doesn't cause monsters, but if you have a monster, you got to get rid of the food you don't want to feed the monster in your house.
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Right, treat the monster, then you can bring back some food.
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And vaginal estrogen is so low dose that it doesn't go into your bloodstream.
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It doesn't make you premenopausal again.
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We'll say that it's just such low dose that if you draw your blood you're still in the postmenopausal range.
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Right, it's incredibly low dose.
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So the fear?
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Fear comes from lack of education.
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You educate women.
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They understand things.
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There still might be 22 years of fear in the zeitgeist and ether right that they and their sister and their neighbor and all these other people that like want to kind of they.
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Of course they love her right.
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But it's like if the people who love you aren't educated, they're going to contribute to throwing the fear on you as well.
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Yeah, absolutely.
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And the other area, when we're talking about vaginal estrogen and I know I actually did a podcast episode with this recently with my good friend Joe Wicks and we were talking about the significant campaign that's underway in the US to remove the black box warning so can you just talk us through that a little bit as well?
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Yeah, does Australia have the boxed warning on it?
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Yeah, we do.
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Yeah, you do.
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Yeah, canada has it too.
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So after the Women's Health Initiative, our FDA so that's our Food and Drug Administration basically said we need to warn everybody about the bad things that the WHI found and they put a very scary label.
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We call it the boxed warning.
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It's like the highest scary label that a medication can have, short of it just being withdrawn as a medication, and it basically says stroke, blood clot, heart attacks, probably, I think liver disease is on there, the cancer is on there, but the most concerning one to me.
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I mean, they're all concerning because they're all wrong, but is that?
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It says probable dementia, and for anybody who knows words, probable means more than possible.
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Yeah, right, so it's like crazy strong wording.
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None of it's correct with the current medications that we commonly use.
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Most menopause experts think the boxed warning should come off of systemic estradiol as well, because that doesn't cause any of these things either.
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In addition, it might actually decrease your risk of dementia and decrease.
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It might actually do the opposite of what.
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The warning is not just neutral.
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So most people think that also needs to come off.
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But the very low hanging fruit is the vaginal estrogen because it's not systemic.
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It's incredibly safe.
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Studies after studies after studies have been shown the safety and efficacy of this medication.
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A good example is like a steroid, right?
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So like a steroid cream that you put on your hand because you got to be touched some plant outside is different than you swallowing high doses of steroids.
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Right, they're both called steroids, but the risks are different.
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And so to take estrogen and throw a warning on every single dose route type of estrogen, that's just simply not how the world works.
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My friend actually published a study last year and they said even if a woman is lucky enough to get a vaginal estrogen prescription, 23% will still not use it because she reads the warning label.
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And if the doctor isn't like, well, if you're a label reader, you're going to read this and it's wrong, right?
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So, and everybody, I see I preemptive and I'm like and I'm sorry because that means you have to decide between me and the FDA and that's a crappy position to be put in.
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But you know, the big petition now is like, people want truth.
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They want truth from government labels.
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I always joke like the other government label that we were talking about changing in America recently is the alcohol warning.
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So the alcohol warning says don't use if you're pregnant and don't operate heavy machinery.
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And I'm like that's a very toxic chemical that's associated with seven different cancers, right.
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And they're like don't operate bulldozers with it.
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It doesn't apply to most people.
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So that's that government wording.
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And then you've got this vaginal estrogen on like a product so safe.
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It's over the counter in the UK, it's over the counter in multiple countries, right, I know that's what I was going to say.
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There are countries where they have now provided availability for it over the counter from a pharmacist.
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Yeah, uk happened, maybe 23.
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That happened.
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Finland's over the counter, I think Israel's over the counter, multiple countries, it's over the counter Probably over the counter in Mexico.
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And just going back to one of the things that you were talking about, with the percentage of women that choose, then, not to use it once they get at home, because they read the warning I'm not sure if it was through you or someone else shared a story recently where the woman that took it home she knew that it was safe to use but her husband happened to pick up the packaging and read it and said I don't want you to use this.
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But I think it also goes into what we were talking about before, and that is, you know, the people that love us the most often try to keep us safe, and they're not necessarily coming from a place of education and information, but that's exactly right, yeah, yeah, hey.
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That's exactly right, yeah, yeah, hey.
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If everybody wants to keep everybody safe, like some people die when they take Viagra, what so do we tell everybody not to take Viagra?
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No, no, we do not.
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No, we do not, and that gets pretty much encouraged.
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Yes, so you know, I always say check our bias yeah.
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Great point.
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Check our bias.
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Yeah, I like that very much, kelly Kelly, one of the other areas I wanted to talk to you a little bit about was testosterone.
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It is something that can be really controversial, particularly here in Australia.
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You guys like making mountains out of molehills.
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I'm learning.
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Not all of us.
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Not all of us.
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Thank you for the clarification, but yes, there is a bit of conjecture and gatekeeping and pushback around the use of testosterone.
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So I'm really keen to hear as you know a urologist and somebody that does see male and female patients, you know, I know where you sit on this, but I'd love for you to just kind of explain to everybody listening your thoughts on the use of testosterone.
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Yeah, so it's kind of like.
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It's kind of like GSM, like you have to step back two, two or three paces because if somebody's, like Dr Casperson, just thinks all women should go on testosterone, I was like, well, no, and you know, a lot of women don't even know that testosterone is in our bodies, and so it's.
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I always now like try to step back and be like okay, just so people, so people can catch up.
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Testosterone is in all bodies four times the amount of estrogen in our bodies, right, so ovaries make testosterone.
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We just have 10 to 20 times less than men.
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Like men make tons of testosterone.
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We make more testosterone than estrogen.
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Right, but if people don't have that understanding first, then they are very confused as to why we're talking about giving a male hormone to women, because they don't know that it's an every body hormone.
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So I always lead with that, because now people are like they're a little bit more open to be like holy crap, are you telling me, ovaries make four times the amount of testosterone and estrogen?
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We don't even talk about replacing it?
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No, we rarely talk about replacing it.
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But testosterone receptors are everywhere in our body, right, you give women testosterone.
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Their clitoral artery has more blood flow in it, like.
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We've measured this right.
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It's cool stuff.
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That is very cool stuff.
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It's super cool stuff, like testosterone helps men with erections.
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Testosterone helps women with erections right, we all have the same body parts, so what's interesting about it is, in the sexual health studies, testosterone actually helps all domains of female sexual health, so lubrication, arousal, orgasm, desire and overall sense of well-being in regards to their sex life.
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That's very important.
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In addition, we've got data that it's good for libido.
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It's not great for libido because libido is incredibly complicated.
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This woman was like I've been on testosterone for a year and I still have low libido.
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Libido is incredibly complicated.
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This woman was like I've been on testosterone for a year and I still have low libido, and I'm like libido is incredibly complicated, right.
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It's like how's your relationship?
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How's your stress?
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Are you sleeping?
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How's work, right?
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Do you have a newborn at home?
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Right?
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All of these things affect libido.
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So the other thing to note, though, is libido is a mood, right.
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Where is libido located in your body?
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Your libido is not located in your heart or your armpit.
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It's in your brain.
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Thus proving that and we've got, you know, mri studies showing testosterone in the brain and how testosterone helps nerve cells and helps myelin and helps mitochondria.
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We've got tons of basic science on testosterone and cell function, mitochondrial health.
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Your body works better with it.
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Now what the problem is is we don't have many people actually studying it currently in female bodies, especially in postmenopausal female bodies, right?
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So it's like it's crazy that 50% of the population isn't being studied on something they make four times the amount of than estrogen.
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I mean this doesn't piss everybody off.
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That's pretty mind-blowing.
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It's pretty mind-blowing.
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In addition, we've been giving women testosterone for 80 years, right Started in the 1940s.